ABSTRACT
The objective of this work was to study the morphology and biometry of the infraorbital foramen (FIO), variations in its shape, size and number as well as to obtain measurements of its location. 60 dry skulls were analyzed. The test of Qui-quadrant and the T Test were used in measurements with a 5 percent significance. On the right side, the FIO was measured at a distance of 6.49(+/-1.68) mm from the lower, 39.65(±3) mm from the upper, 17.7(+/-2.97) mm from the medial and 20.46(+/-2.9) mm from the lateral margin of the orbit; its pear-shaped opening distance was 13.67(+/-2.17) mm. On the left side, the distance of the FIO to the lower margin of the orbit was 6.52(+/-1.82) mm; to the upper margin was 39.9(+/-2.62) mm and to the lateral and medial margin were 17.93(+/-2.58) mm and 21.12(+/-3) mm, respectively; its distance to the pear-shaped opening was 14.26(+/-1.83) mm. It was found predominately in an oval shape, in 39 (65 percent) of the skulls, on both sides. Accessory foramens were present in 11 samples on the right and in 15 samples on the left side. The FIO was most frequently found on the side of, or laterally to the sagittal plane that passes through the middle of the supraorbital foramen/ incisures, in 38 skulls (63.3 percent) on the right side and in 45 skulls (75 percent) on the left and middle to the zigomatic-maxillary suture, in 41 skulls (68.3 percent) on right and in 42 skulls (70 percent) on the left side, besides being most frequently found in a region between the first and second premolars, in 22 skulls (36.7 percent) on the right side and in 17 skulls (28.3 percent) on the left...
El objetivo de este trabajo fue estudiar la morfología y biometría del foramen infraorbitario (FIO), las variaciones en su forma, tamaño y número y además, determinó su ubicación.Se utilizaron 60 cráneos aplicándose las prueba de Chi-cuadrado y t student con una significancia del 5 por ciento.En el lado derecho, la distancia del FIO al margen inferior de la órbita fue de 6,49 (+/- 1,68) mm, 39,65 mm (+/- 3) al margen superior mm, 17,7 mm (+/- 2,97) al margen medial y 20,46 (+/- 2,9) y al margen lateral de la órbita, respectivamente. La distancia de apertura fue 13,67 (+/- 2,17) mm.En el lado izquierdo, la distancia del FIO al margen inferior de la órbita fue 6,52 (+/- 1,82) mm; al margen superior fue 39,9 (+/- 2,62) mm y a los márgenes lateral y medial fue 17,93 (+/- 2,58) mmy 21,12 (+/- 3) mm, respectivamente. La distancia a la abertura piriforme fue 14,26 (+/- 1,83) mm. Su forma era predominantemente ovalada, en 39 (65 por ciento) de los cráneos. Forámenes accesorios estaban presentes en 11 muestras en el lado derechoy en 15 muestras en el lado izquierdo.El FIO estaba localizado más frecuentemente lateral al plano sagital que pasa por el centro del foramen supraorbital. De estos casos, en 38 cráneos (63,3 por ciento) en el lado derecho y en 45 cráneos (75 por ciento) en el lado izquierdo.Los FIO estaban en el punto medio de la sutura cigomática-maxilar en 41 cráneos (68,3 por ciento) en el lado derecho y en 42 cráneos (70 por ciento) en el lado izquierdo. Los FIO estaban más frecuentemente localizados en relación al primer y segundo premolares, en 22 cráneos (36,7 por ciento) en el lado derecho y en 17 cráneos (28,3 por ciento) en el lado izquierdo...
Subject(s)
Humans , Adult , Skull/anatomy & histology , Orbit/anatomy & histology , Acupuncture , Cephalometry , Chi-Square DistributionABSTRACT
It has been suggested that the measurement of metronidazole clearance is a sensitive method for evaluating liver function. The aim of this study was to evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole ratios as indicators of dynamic liver function to detect changes resulting from the various forms of chronic hepatitis C virus (HCV) infection. A total of 139 individuals were studied: 14 healthy volunteers, 22 healthy, asymptomatic, consecutive anti-HCV-positive HCV-RNA negative subjects, 81 patients with chronic hepatitis C (49 with moderate/severe chronic hepatitis and 34 with mild hepatitis), and 20 patients with cirrhosis of the liver. HCV status was determined by the polymerase chain reaction. Plasma concentrations of metronidazole and its hydroxy-metabolite were measured by reverse-phase high-performance liquid chromatography with ultraviolet detection in a blood sample collected 10 min after the end of a metronidazole infusion. Anti-HCV-positive HCV-RNA-negative individuals demonstrated a significantly reduced capacity to metabolize intravenously infused metronidazole compared to healthy individuals (0.0478 ± 0.0044 vs 0.0742 ± 0.0232). Liver cirrhosis patients also had a reduced plasma hydroxy-metronidazole/metronidazole ratio when compared to the other groups of anti-HCV-positive individuals (0.0300 ± 0.0032 vs 0.0438 ± 0.0027 (moderate/severe chronic hepatitis) vs 0.0455 ± 0.0026 (mild chronic hepatitis) and vs 0.0478 ± 0.0044 (anti-HCV-positive, HCV-RNA-negative individuals)). These results suggest an impairment of the metronidazole metabolizing system induced by HCV infection that lasts after viral clearance. In those patients with chronic hepatitis C, this impairment is paralleled by progression of the disease to liver cirrhosis.